Oil Free Revitalizing Serum with Juveleven peptide | Return to Eden – www.returntoedencosmetics.com

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Abigail's Serum by Return to Eden Cosmetics in a 1 oz airless bottle with light pink label against a white background with a sprig of blooming silver sage behind the bottle
Return to Eden's Abigail Oil Free Serum in a 1 oz airless bottle sitting on shiplap background
back of Abigail's Serum by Return to Eden showing full ingredients list. 1 oz airless bottle with pink background is shown on a bed of green thyme
Abigail's Serum with white background and clay flowerpot with blooming African violet
bottle of Abigail's serum lying next to blooming fuschia colored azaleas

Abigail's Serum

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Oil Free Protective Serum with the Skin Revitalizing Peptide, Juveleven

The Science behind the formula

Before I tell you why I named this serum Abigail, let's talk about Juveleven.  This peptide with the technical name, Acetyl Hexapeptide-51 Amide, works along a particular biomolecular pathway to promote clearance of senescent skin cells, specifically fibroblasts, which are responsible for generating collagen and other components of the extracellular matrix.

Senescent fibroblasts no longer divide and no longer support tissue structures (think creating new skin cells, forming collagen and making hyaluronic acid and all the other components or our skin's extraceullular matrix) AND these cells take on a different shape than viable fibroblasts.  

Plus, these senescent cells are harming our skin by releasing pro-inflammatory cytokines (cell signaling molecules) and matrix metalloproteinases, which are enzymes that degrade the extracellular matrix.  And, senescent cells also release signaling molecules that can promote nearby skin cells to enter senescence as well.

Now, one of the jobs of our immune system is to get rid of these senescent cells, but as we age, our immune system becomes less efficient at "taking out the trash" and senescent cells begin to build up promoting the appearance of aged skin.

Juveleven, is a multi-functional peptide that helps reduce the number of senescent skin cells.  It does this by biomolecular mimicry and I'll cover the biochemistry in a future blog post, but basically this peptide has been shown to do the following:

  • Reduce DNA damage to UV exposed cells
  • Promote younger acting skin by reducing the number of senescent skin cells
  • Reduce damage to cells due to environmental pollution

Juveleven is not the only peptide in this product, but it is the main reason why I named this product Abigail's Serum.

Why is this product called Abigail's Serum?

For me, Abigail's story is one of the most magnetic in the Old Testament.  Abigail not only had exquisite physical beauty but intelligence to match.  I imagine Abigail as a generous, joyful woman who's outer appearance mirrors her inner beauty, and who ages gracefully due to her good-hearted nature.

I always see Abigail as a woman in her 30s (the decade where most of us girls first start to notice our crow's feet, the laugh line that never fully goes away regardless of our expression) when David first meets her.  While she was endowed with physical beauty, I still imagine her character covered any signs of aging.

While I can't package Abigail's character, I can offer this oil free serum deliberately crafted to protect and revitalize skin.  The peptides included in this serum were selected for their protective and healing properties.  These three peptides are paired with ingredients (sodium hyaluronate and panthenol) to prevent trans epidermal water loss (TEWL).  Hydration is further boosted with the natural moisturizing factor (NMF) sodium PCA.

More about the peptides

Juveleven, Acetyl Hexapeptide-51 Amide, is discussed in detail under the science section above, so we'll move on to the other two peptides.

The peptide, Diaminopropionoyl Tripeptide-33 (Preventhelia) offers both sun protection and healing by helping scavenge free radical species (thus preventing cellular damage during sun exposure) and repairing DNA (post-sun exposure).

I have been adding Diaminopropionoyl Tripeptide-33 (Preventhelia) to all lotions I use (whether I make them or buy them) for treating sun exposed skin for nearly a decade, and the difference in treated skin vs. untreated skin is profound in the published studies I've seen*.

The peptide, Acetyl Tetrapeptide-40 (Telangyn), has anti-inflammatory properties and has been shown to reduce redness, so whether you're battling redness due to sun exposure or rosacea, this peptide helps keep redness at bay by reducing inflammation*. 

*None of the claims above have been evaluated or substantiated by the FDA.

How to use

This serum may be used both day or night alone, on top, or underneath all other products. It leaves the skin with a silky feel and could easily replace your makeup primer (one less product you need in your skincare routine - who's not down for that?).

A little bit of this product spreads very well, so a little goes a long way.  If you dispense too much, don't forget about your décollatage.  You may wind up loving this serum so much you want to use it on your hands and forearms as well.

Who's this product for?

Abigail's Serum is recommended for all skin types and is especially suitable for you if you're interested in protecting your skin from environmental aging stressors such as UV light and revitalizing your skin if you're experiencing those first signs of aging or have noticed a little lackluster in your appearance.

It is fragrance free with no added essential oils or synthetic fragrances.  Extremely clean formula (only 14 ingredients including 3 peptides, 3 moisturizing agents, and 2 skin soothing ingredients) well suited for sensitive skin types.

More Information

Available Sizes:  1 fl. oz. 

Target pH

6.0 (6.0 is targetted for all our products unless otherwise specified as this is the pH I've had the best results with for reducing acne breakouts while still being suitable for dry skin).


Water, Aloe barbadensis Leaf Juice, Panthenol (Provitamin B-5), Certified Organic Cucumis sativus (Cucumber) Distillate, Sodium PCA, Sodium Hyaluronate, Acetyl Tetrapeptide-40, Diaminopropionoyl Tripeptide-33, Acetyl Hexapeptide-51 Amide, Sodium Bicarbonate, Butylene Glycol, Disodium EDTA, Caprylyl Glycol, Phenoxyethanol

California Prop 65 Statement

The following statement is made in order to comply with the California Safe Drinking Water and Toxic Enforcement Act of 1986. This product is not known to the State of California to cause cancer, birth defects or other reproductive harm.

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